Nilanjan

Nilanjan Chatterjee, PhD

Bloomberg Distinguished Professor

Department of Biostatistics, Bloomberg School of Public Health Department of Oncology, School of Medicine

Johns Hopkins University

Contact:
Johns Hopkins Bloomberg School of Public Health
Department of Biostatistics
615 N Wolfe Street
Baltimore, MD 21205
Phone: 410-502-8971
Fax: 410-955-0958
E-Mail: nilanjan@jhu.edu
Administrative Coordinator:
Kim Clay
Phone:  410-955-3067
Email:  kphilpo3@jhmi.edu

MRMix

DESCRIPTION

 

Description

R package for two-sample Mendelian randomization analysis using mixture models. For numerical stability, we recommend using summary statistics in the standardized scale, i.e.

  • 1) for continuous phenotype, the beta and SE when both the genotypes and phenotypes are standardized to have variance 1;
  • 2) for binary phenotype, the beta and SE when the genotypes are standardized to have variance 1.

Causal estimates are interpreted as standard deviation (SD) unit increase (continuous outcome) or log-OR (binary outcome) of Y per SD unit increase in X (assumed to be continous). If standardized-scale summary statistics are not available, users may use z-statistics and effective sample size to transform their summary statistics to the standardized scale. See Example or type ?MRMix for more information.

 

System requirements

MRMix can be used on any operating system. R needs to be installed. Package devtools is required for the installation.

Installation

devtools::install_github("gqi/MRMix")